Evidence supporting the use of: Resveratrol
For the health condition: Colitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol is a polyphenolic compound found naturally in grapes, berries, and peanuts, and has attracted interest for its potential anti-inflammatory and antioxidant properties. Scientific studies, primarily in preclinical models, suggest that resveratrol may offer benefits in managing colitis, an inflammatory bowel disease. In various animal models of colitis (e.g., dextran sulfate sodium-induced colitis in mice), resveratrol supplementation has been shown to decrease inflammation, reduce oxidative stress, and improve histological markers of colon tissue health. These effects are hypothesized to be mediated by inhibition of pro-inflammatory cytokines (such as TNF-α and IL-1β), suppression of the NF-κB signaling pathway, and enhancement of antioxidant enzyme activity.

Small pilot human studies are limited but have shown some promise. For example, a 2016 randomized, double-blind, placebo-controlled clinical trial found that resveratrol supplementation in patients with ulcerative colitis led to significant reductions in disease activity and inflammatory markers compared to placebo. However, these human studies are few, and larger well-designed clinical trials are needed before resveratrol can be recommended as a standard treatment.

In summary, while there is scientific interest and encouraging preclinical data for resveratrol in colitis, clinical evidence remains preliminary. Its use is justified by early-stage scientific investigation rather than tradition or robust clinical validation, meriting a moderate evidence rating.

More about resveratrol
More about Colitis

Other ingredients used for Colitis

Akkermansia muciniphila
algal oil
Aloe vera
anthocyanins
apple
astaxanthin
bacillus clausii
bacillus coagulans
bacillus subtilis
barberry
beta caryophyllene
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bilberry
bio ecolian (proprietary)
blueberry
bromelain
butyrate triglyceride
cat's claw
Chinese salvia root
chlorella
Coptis chinensis
cowage seed
turmeric
curcumin
fiber blend (proprietary)
flavonols
garlic bulb
ginger
green tea
hemp oil
immunoglobin G
inulin
isomalto-oligosaccharide
L-glutamine
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus lactis
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus lactis
Lactoferrin
licorice root
N-acetyl-cysteine (NAC)
plantain
pomegranate
prebiotic blend (proprietary)
butyric acid
quercetin
resveratrol
Saccharomyces boulardii
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Triphala
Zinc
xanthium (cockleburs)
blackboard tree
picrorhiza kurroa
Swertia
buckthorn
anemarrhena asphodeloides
Algae
apple cider vinegar
apigenin
anamu
Alchornea
andrographolide
Asteraceae
Acemannan
Amor seco
astragalin
Bifidobacterium
Bifidobacterium adolescentis
Boswellic Acid
bael
Basidiomycota
Boswellia
Baccharoides anthelmintica
Bifidobacterium animalis
back nightshade
bacteria
Bifidobacteria
Bacillus
cactus
Curcuminoid
curcumen
Curcuma
cabbage
Clostridium butyricum
colocynth
diterpenes
Euphorbia
fucoidan
fiber
Frangula
gallic acid
Glycomacropeptides
Guava
Glycyrrhetinic acid
Hedyotis
Helicteres isora
Humic acid
hericium mushroom
Immunoglobulin G
Kefir
Lactobacillus plantarum
Lactobacillus pentosus
Lactobacillus sakei
Lactobacillus kefiri
Lactococcus rhamnosus
Lactococcus casei
Lactobacillus delbrueckii
Lactobacillus johnsonii
Lactobacillus
L. lactis
Mucilage
Nimbidin
Oligosaccharides
Oxymatrine
Osthole
polysaccharides
Plantago
phlorotannins
Propionibacterium freudenreichii
probiotics
Pediococcus acidilactici
Patrinia
Peptides
rosmarinic acid
Rhus coriaria
reed herb
Slippery Elm
Scabrous Gentian
Triterpenes
Tayuya
Trametes
Varuna

Products containing resveratrol

Vitabase Active Woman's Multi
Thorne Advanced Nutrients Multivitamin
Designs For Health ArthroSoothe™
Designs For Health ArthroSoothe™ Supreme
Pure Encapsulations Balanced Immune
Designs For Health BioFizz® Immune
Designs For Health CellGuard-NR 60 Capsules
Designs For Health FemGuard+Balance™
Designs For Health Inflammatone™
Designs For Health Inflammatone™
Klean Athlete Klean Multivitamin ™
Thorne L-Arginine Plus Perfusia Plus
Pure Encapsulations Memory Pro
Pure Encapsulations Memory Pro
Pure Encapsulations Metabolic Xtra
Douglas Laboratories Methlyated Resveratrol Plus
Pure Encapsulations Mitochondria-ATP
Designs For Health Mitochondrial NRG™
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Thorne PolyResveratrol-SR
Designs For Health Primal Multi™
Pure Encapsulations Renual
Pure Encapsulations ResCu-SR®
Thorne ResveraCel
Pure Encapsulations Resveratrol
Pure Encapsulations Resveratrol
Douglas Laboratories Resveratrol
Pure Encapsulations Resveratrol Extra
Pure Encapsulations Resveratrol Extra
Designs For Health Resveratrol Supreme
Integrative Therapeutics Resveratrol Ultra HP 175mg
Pure Encapsulations Resveratrol VESIsorb®
Pure Encapsulations RevitalAge™ Ultra
Designs For Health Ultimate Antiox Full Spectrum
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Pure Encapsulations Ultra Pure Pack
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
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Vitabase Women's Support