Evidence supporting the use of: Rosmarinic acid
For the health condition: Colitis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rosmarinic acid is a naturally occurring polyphenolic compound found in several culinary and medicinal herbs, most notably in rosemary (Rosmarinus officinalis) and perilla (Perilla frutescens). Its use for colitis is primarily supported by preclinical scientific studies, rather than by traditional medicine or robust clinical trials in humans.

Animal studies, particularly in rodent models of colitis (such as dextran sulfate sodium [DSS]-induced colitis), have repeatedly shown that rosmarinic acid can reduce disease severity. The mechanism appears to involve its antioxidant, anti-inflammatory, and immunomodulatory properties. Research indicates that rosmarinic acid reduces levels of inflammatory cytokines like TNF-α and IL-6, inhibits NF-κB activation, and decreases oxidative stress in the colon. Histological analysis in these models often reveals reduced mucosal damage and inflammatory infiltration following treatment with rosmarinic acid.

Despite these promising preclinical results, there is a lack of well-designed clinical trials in humans evaluating the efficacy or safety of rosmarinic acid for colitis. Thus, while the scientific rationale exists, the evidence is limited to animal and in vitro models. As such, the strength of evidence supporting its use in humans for colitis remains low (rated 2/5), and its clinical application cannot be recommended without further human studies.

More about rosmarinic acid
More about Colitis

Other ingredients used for Colitis

Akkermansia muciniphila
algal oil
Aloe vera
anthocyanins
apple
astaxanthin
bacillus clausii
bacillus coagulans
bacillus subtilis
barberry
beta caryophyllene
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bilberry
bio ecolian (proprietary)
blueberry
bromelain
butyrate triglyceride
cat's claw
Chinese salvia root
chlorella
Coptis chinensis
cowage seed
turmeric
curcumin
fiber blend (proprietary)
flavonols
garlic bulb
ginger
green tea
hemp oil
immunoglobin G
inulin
isomalto-oligosaccharide
L-glutamine
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus lactis
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus lactis
Lactoferrin
licorice root
N-acetyl-cysteine (NAC)
plantain
pomegranate
prebiotic blend (proprietary)
butyric acid
quercetin
resveratrol
Saccharomyces boulardii
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Triphala
Zinc
xanthium (cockleburs)
blackboard tree
picrorhiza kurroa
Swertia
buckthorn
anemarrhena asphodeloides
Algae
apple cider vinegar
apigenin
anamu
Alchornea
andrographolide
Asteraceae
Acemannan
Amor seco
astragalin
Bifidobacterium
Bifidobacterium adolescentis
Boswellic Acid
bael
Basidiomycota
Boswellia
Baccharoides anthelmintica
Bifidobacterium animalis
back nightshade
bacteria
Bifidobacteria
Bacillus
cactus
Curcuminoid
curcumen
Curcuma
cabbage
Clostridium butyricum
colocynth
diterpenes
Euphorbia
fucoidan
fiber
Frangula
gallic acid
Glycomacropeptides
Guava
Glycyrrhetinic acid
Hedyotis
Helicteres isora
Humic acid
hericium mushroom
Immunoglobulin G
Kefir
Lactobacillus plantarum
Lactobacillus pentosus
Lactobacillus sakei
Lactobacillus kefiri
Lactococcus rhamnosus
Lactococcus casei
Lactobacillus delbrueckii
Lactobacillus johnsonii
Lactobacillus
L. lactis
Mucilage
Nimbidin
Oligosaccharides
Oxymatrine
Osthole
polysaccharides
Plantago
phlorotannins
Propionibacterium freudenreichii
probiotics
Pediococcus acidilactici
Patrinia
Peptides
rosmarinic acid
Rhus coriaria
reed herb
Slippery Elm
Scabrous Gentian
Triterpenes
Tayuya
Trametes
Varuna

Products containing rosmarinic acid

We currently have no products on Vitabase that contain this ingredient.