Evidence supporting the use of: Sodium Butyrate
For the health condition: Colitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sodium butyrate, a short-chain fatty acid (SCFA), is increasingly studied for its potential to support or treat colitis, particularly ulcerative colitis and other forms of inflammatory bowel disease (IBD). Scientific evidence supporting its use comes primarily from preclinical animal studies and a limited number of small human trials. Butyrate is a primary energy source for colonocytes and plays a crucial role in maintaining intestinal barrier function, modulating immune responses, and reducing inflammation.

Animal models of colitis have consistently demonstrated that oral or rectal administration of sodium butyrate can reduce inflammation, improve mucosal healing, and modulate the gut microbiome. In humans, several small clinical trials and pilot studies—often using rectal enemas of sodium butyrate—have reported improvements in symptoms and endoscopic scores in patients with distal ulcerative colitis or proctitis. However, evidence is mixed, and some studies have failed to show significant benefit compared to placebo or standard therapy.

The overall clinical evidence remains limited by small sample sizes, short duration, and variability in formulations and administration routes. There are no large-scale, definitive randomized controlled trials establishing sodium butyrate as a standard therapy for colitis. Nevertheless, the biological rationale and preliminary results provide a scientific basis for its investigation, justifying a moderate evidence rating.

More about Sodium Butyrate
More about Colitis

Other ingredients used for Colitis

Akkermansia muciniphila
algal oil
Aloe vera
anthocyanins
apple
astaxanthin
bacillus clausii
bacillus coagulans
bacillus subtilis
barberry
beta caryophyllene
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bilberry
bio ecolian (proprietary)
blueberry
bromelain
butyrate triglyceride
cat's claw
Chinese salvia root
chlorella
Coptis chinensis
cowage seed
turmeric
curcumin
fiber blend (proprietary)
flavonols
garlic bulb
ginger
green tea
hemp oil
immunoglobin G
inulin
isomalto-oligosaccharide
L-glutamine
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus lactis
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus lactis
Lactoferrin
licorice root
N-acetyl-cysteine (NAC)
plantain
pomegranate
prebiotic blend (proprietary)
butyric acid
quercetin
resveratrol
Saccharomyces boulardii
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Triphala
Zinc
xanthium (cockleburs)
blackboard tree
picrorhiza kurroa
Swertia
buckthorn
anemarrhena asphodeloides
Algae
apple cider vinegar
apigenin
anamu
Alchornea
andrographolide
Asteraceae
Acemannan
Amor seco
astragalin
Bifidobacterium
Bifidobacterium adolescentis
Boswellic Acid
bael
Basidiomycota
Boswellia
Baccharoides anthelmintica
Bifidobacterium animalis
black nightshade
bacteria
Bifidobacteria
Bacillus
cactus
Curcuminoid
curcumen
Curcuma
cabbage
Clostridium butyricum
colocynth
diterpenes
Euphorbia
fucoidan
fiber
Frangula
gallic acid
Glycomacropeptides
Guava
Glycyrrhetinic acid
Hedyotis
Helicteres isora
Humic acid
hericium mushroom
Immunoglobulin G
Kefir
Lactobacillus plantarum
Lactobacillus pentosus
Lactobacillus sakei
Lactobacillus kefiri
Lactococcus rhamnosus
Lactococcus casei
Lactobacillus delbrueckii
Lactobacillus johnsonii
Lactobacillus
L. lactis
Mucilage
Nimbidin
Oligosaccharides
Oxymatrine
Osthole
polysaccharides
Plantago
phlorotannins
Propionibacterium freudenreichii
probiotics
Pediococcus acidilactici
Patrinia
Peptides
rosmarinic acid
Rhus coriaria
Slippery Elm
Scabrous Gentian
Triterpenes
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Trametes
Varuna

Products containing Sodium Butyrate

We currently have no products on Vitabase that contain this ingredient.