Evidence supporting the use of: Transforming growth factor beta
For the health condition: Colitis
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Transforming growth factor beta (TGF-β) is a multifunctional cytokine involved in the regulation of immune responses and tissue repair. Its use in the context of colitis, particularly inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn’s disease, is supported by preclinical and some clinical research. TGF-β is known for its anti-inflammatory properties; it suppresses the activation and proliferation of immune cells that drive intestinal inflammation and promotes epithelial cell restitution and mucosal healing. Experimental models of colitis in animals have demonstrated that administration of TGF-β or enhancement of its signaling can reduce inflammation, decrease histological damage, and improve clinical symptoms. In humans, direct administration of TGF-β is not standard practice due to challenges with delivery, potential off-target effects, and fibrogenic (scarring) risk. However, therapies designed to enhance TGF-β signaling, such as the use of TGF-β-rich enteral nutrition formulas (e.g., Modulen IBD), have been explored and are part of some nutritional strategies for pediatric Crohn’s disease. Additionally, altered TGF-β signaling has been implicated in the pathogenesis of IBD, and strategies to restore normal TGF-β activity are under investigation. Overall, while animal and some human studies suggest beneficial effects, the evidence is moderate, and TGF-β-based therapies are not yet routine clinical practice for colitis. Ongoing research aims to clarify its therapeutic potential and safety in this context.
More about Transforming growth factor beta
More about Colitis
Other ingredients used for Colitis
Akkermansia muciniphilaalgal oil
Aloe vera
anthocyanins
apple
astaxanthin
bacillus clausii
bacillus coagulans
bacillus subtilis
barberry
beta caryophyllene
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bilberry
bio ecolian (proprietary)
blueberry
bromelain
butyrate triglyceride
cat's claw
Chinese salvia root
chlorella
Coptis chinensis
cowage seed
turmeric
curcumin
fiber blend (proprietary)
flavonols
garlic bulb
ginger
green tea
hemp oil
immunoglobin G
inulin
isomalto-oligosaccharide
L-glutamine
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus lactis
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus lactis
Lactoferrin
licorice root
N-acetyl-cysteine (NAC)
plantain
pomegranate
prebiotic blend (proprietary)
butyric acid
quercetin
resveratrol
Saccharomyces boulardii
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Triphala
Zinc
xanthium (cockleburs)
blackboard tree
picrorhiza kurroa
Swertia
buckthorn
anemarrhena asphodeloides
Algae
apple cider vinegar
apigenin
anamu
Alchornea
andrographolide
Asteraceae
Acemannan
Amor seco
astragalin
Bifidobacterium
Bifidobacterium adolescentis
Boswellic Acid
bael
Basidiomycota
Boswellia
Baccharoides anthelmintica
Bifidobacterium animalis
black nightshade
bacteria
Bifidobacteria
Bacillus
cactus
Curcuminoid
curcumen
Curcuma
cabbage
Clostridium butyricum
colocynth
diterpenes
Euphorbia
fucoidan
fiber
Frangula
gallic acid
Glycomacropeptides
Guava
Glycyrrhetinic acid
Hedyotis
Helicteres isora
Humic acid
hericium mushroom
Immunoglobulin G
Kefir
Lactobacillus plantarum
Lactobacillus pentosus
Lactobacillus sakei
Lactobacillus kefiri
Lactococcus rhamnosus
Lactococcus casei
Lactobacillus delbrueckii
Lactobacillus johnsonii
Lactobacillus
L. lactis
Mucilage
Nimbidin
Oligosaccharides
Oxymatrine
Osthole
polysaccharides
Plantago
phlorotannins
Propionibacterium freudenreichii
probiotics
Pediococcus acidilactici
Patrinia
Peptides
rosmarinic acid
Rhus coriaria
Slippery Elm
Scabrous Gentian
Triterpenes
Tayuya
Trametes
Varuna
Other health conditions supported by Transforming growth factor beta
AbrasionsArthritis
Autoimmune Disorders
Broken Bones
Burns and Scalds
Cancer Treatment (reducing side effects)
Colitis
Crohn's Disease
Cuts
Dermatitis
Gingivitis
Inflammation
Inflammatory Bowel Disorders
Injuries
Lupus
Multiple Sclerosis
Nerve Damage
Osteoporosis
Scars / Scar Tissue
Surgery (healing from)
Ulcers
Wounds and Sores
