Evidence supporting the use of: Polyethylene glycol
For the health condition: Colon (spastic)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Polyethylene glycol (PEG) is a widely used osmotic laxative that has robust scientific evidence supporting its efficacy in the treatment of various forms of constipation, including constipation associated with spastic colon (also known as irritable bowel syndrome with constipation, or IBS-C). PEG works by retaining water in the stool, resulting in softer stools and promoting bowel movements without significant electrolyte disturbances or colonic irritation. Multiple randomized controlled trials and meta-analyses have demonstrated that PEG is effective and well-tolerated in relieving chronic constipation symptoms, including those seen in IBS-C. According to guidelines from the American College of Gastroenterology and other expert bodies, PEG is recommended as a first-line therapy for chronic constipation and is considered suitable for use in patients with spastic colon presenting with constipation. PEG is not absorbed systemically and has a favorable safety profile, making it appropriate for long-term use in adults and children. However, it is not curative and does not address the underlying pathophysiology of spastic colon but rather provides symptomatic relief. In summary, scientific validation for the use of polyethylene glycol to treat constipation in spastic colon is strong, and its use is based on high-quality clinical evidence.

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