Evidence supporting the use of: 1,3,7-Trimethylpurine-2,6-dione
For the health condition: Concentration (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

1,3,7-Trimethylpurine-2,6-dione is the chemical name for caffeine, a well-known central nervous system stimulant. The use of caffeine to support or improve concentration is supported by substantial scientific evidence. Numerous controlled studies have demonstrated that caffeine can enhance various aspects of cognitive function, including alertness, vigilance, attention, and reaction time, particularly in situations of fatigue or suboptimal alertness. The mechanism is primarily attributed to caffeine’s antagonism of adenosine receptors in the brain, leading to increased neuronal activity and the release of neurotransmitters like dopamine and norepinephrine. Systematic reviews and meta-analyses have generally found that moderate doses of caffeine (roughly 40-300 mg) can acutely improve concentration and sustained attention in healthy adults. However, the effects can vary by individual, and tolerance may develop with regular use. It is also important to note that excessive intake can lead to adverse effects such as jitteriness, insomnia, and increased heart rate. While caffeine is not a treatment for medically diagnosed attention disorders (such as ADHD), its efficacy in supporting general cognitive performance and concentration in the healthy population is well validated in the literature.

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