Evidence supporting the use of: Nicotinamide riboside
For the health condition: Concentration (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotinamide riboside (NR) is a form of vitamin B3 and a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in cellular metabolism, energy production, and DNA repair. Some scientific interest has emerged regarding NR supplementation to support cognitive functions, including concentration, based on its role in cellular energy and neuroprotection.

Preclinical studies, primarily in animal models, indicate that increasing NAD+ levels via NR supplementation may have neuroprotective effects, improve mitochondrial function, and potentially enhance cognitive performance. A few small-scale human studies and pilot trials have explored NR’s impact on cognitive function, but these studies are limited, often involve older adults or populations with neurodegenerative conditions, and do not specifically target “poor concentration” as a primary endpoint.

To date, there is insufficient direct clinical evidence to confirm that NR supplementation significantly improves concentration in healthy individuals or those with cognitive complaints. The rationale for its use is mostly extrapolated from its general cellular and neurological benefits observed in basic research. Therefore, while there is a scientific basis for interest in NR for brain health, the clinical evidence specifically supporting its use for poor concentration is limited and preliminary, justifying a modest evidence score.

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