Evidence supporting the use of: Paraxanthine
For the health condition: Concentration (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Paraxanthine is a primary metabolite of caffeine in humans and shares a similar chemical structure and pharmacology. Its effects on concentration are supported by emerging scientific evidence, though the body of research is smaller compared to caffeine itself. Several studies suggest that paraxanthine acts as a central nervous system stimulant by antagonizing adenosine receptors, thereby reducing fatigue and increasing alertness and cognitive performance. In recent years, paraxanthine has gained attention as a supplement ingredient due to its potentially cleaner side effect profile compared to caffeine—showing less impact on blood pressure and sleep but providing similar or even enhanced benefits for focus and vigilance.

Preclinical research and a few human trials indicate that paraxanthine may enhance attention, working memory, and reaction time. For instance, published studies have demonstrated that paraxanthine administration improves psychomotor vigilance and sustained attention in healthy adults. However, large-scale, long-term clinical trials are still lacking, and most evidence is derived from acute dosing studies or indirect extrapolation from caffeine research. Overall, while the rationale for using paraxanthine to support concentration is scientifically grounded, the strength of evidence is moderate at present—warranting a cautious but optimistic outlook regarding its efficacy.

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Products containing paraxanthine

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