Evidence supporting the use of: Vitamin B1 (Sulbutiamine)
For the health condition: Concentration (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulbutiamine is a synthetic derivative of vitamin B1 (thiamine) that has been explored for its potential cognitive-enhancing properties, including its effects on concentration. The scientific evidence supporting its use for improving concentration is limited but does exist. Several small clinical studies and animal research have suggested that sulbutiamine may improve symptoms of fatigue and enhance certain aspects of cognitive performance, especially in individuals with asthenia (physical and mental weakness). Some open-label and placebo-controlled trials have reported subjective improvements in attention and mental energy, particularly in patients with fatigue or after infections. However, robust, large-scale randomized controlled trials specifically targeting concentration in healthy individuals are lacking. The mechanism by which sulbutiamine may support cognitive function is thought to involve increased thiamine levels in the brain, modulation of cholinergic and glutamatergic neurotransmission, and enhanced synaptic transmission. Despite some positive findings, the overall evidence base is weak and often methodologically limited, so sulbutiamine is not widely recommended as a first-line treatment for poor concentration in clinical guidelines. Its use for this purpose is primarily found in nootropic and supplement communities, with modest scientific validation.

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