Evidence supporting the use of: Citicholine
For the health condition: Confusion
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Citicoline (also known as CDP-choline) has been studied for its potential cognitive benefits, particularly in the context of acute and chronic neurological conditions that can cause confusion, such as stroke, traumatic brain injury, and vascular dementia. Several randomized controlled trials and meta-analyses have evaluated citicoline’s efficacy in improving cognitive function, including symptoms like confusion, memory impairment, and attention deficits.
The scientific rationale for citicoline’s use centers on its role as a precursor for the synthesis of phosphatidylcholine, a major component of neuronal cell membranes, and the neurotransmitter acetylcholine, which is critical for memory and cognition. Citicoline is also thought to have neuroprotective properties, including the reduction of free radical formation and support of neuronal repair mechanisms.
Clinical evidence is mixed but generally positive for mild to moderate cognitive impairment. For example, a 2014 Cochrane review concluded that citicoline may improve memory and behavior in people with cognitive impairment, although the overall quality of evidence was considered moderate. Some studies in stroke patients have shown improvements in mental status and reductions in confusion, while others have not demonstrated significant benefits. The heterogeneity of study designs and patient populations makes it difficult to draw firm conclusions, but the use of citicoline for confusion is supported by a moderate body of scientific evidence, especially in cases related to neurological injury or disease.
Other health conditions supported by Citicholine
Alzheimer's DiseaseAttention Deficit Disorder
Concussions
Confusion
Dementia
Depression
Memory and Brain Function
Strokes