Evidence supporting the use of: Lion's mane
For the health condition: Confusion

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion’s mane mushroom (Hericium erinaceus) has garnered scientific interest for its potential cognitive benefits, including support for symptoms such as confusion, mild cognitive impairment, and general mental clarity. Preclinical research indicates that compounds in lion’s mane, such as hericenones and erinacines, may stimulate the production of nerve growth factor (NGF), a protein important for the survival and function of neurons. Several small human studies have explored its effects on cognitive function. For example, a 2009 double-blind, placebo-controlled study in elderly Japanese subjects with mild cognitive impairment found that daily supplementation with lion’s mane extract for 16 weeks led to modest but statistically significant improvements in cognitive function compared to placebo; however, benefits diminished after discontinuation. Other small-scale studies and animal models have suggested neuroprotective, anti-inflammatory, and antioxidant effects that could theoretically contribute to improved cognition and reduced confusion.

Despite these promising findings, the overall quality and quantity of human research is limited. Sample sizes are small, study durations are short, and most research focuses on mild cognitive impairment rather than acute confusion or delirium. Therefore, while lion’s mane is used to support cognitive health, the evidence specifically for treating confusion is preliminary and not robust. More rigorous, large-scale clinical trials are needed before lion’s mane can be confidently recommended for confusion or related symptoms.

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