Evidence supporting the use of: Adrenergic amines
For the health condition: Congestion (bronchial)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Adrenergic amines, such as epinephrine and related compounds (including pseudoephedrine and phenylephrine), are well-established agents in the treatment of bronchial congestion. These compounds exert their effects by stimulating adrenergic receptors, particularly the alpha and beta receptors in the respiratory tract. Activation of these receptors leads to vasoconstriction (via alpha receptors) and bronchodilation (via beta-2 receptors), which reduces mucosal edema and opens up the airways, providing symptomatic relief from congestion.

Numerous clinical studies and decades of medical use have validated the efficacy of adrenergic amines in managing symptoms of bronchial congestion, particularly in acute settings such as asthma exacerbations or allergic reactions. For example, inhaled beta-agonists (like albuterol, a selective beta-2 adrenergic agonist) are frontline therapies for bronchospasm and associated congestion. Oral and topical forms of adrenergic amines such as pseudoephedrine and phenylephrine are commonly used as decongestants in over-the-counter cold and flu preparations.

However, the use of non-selective adrenergic amines carries risks, such as increased heart rate, hypertension, and central nervous system stimulation, which limits their use in certain populations. Despite these risks, the therapeutic rationale and mechanism of action for adrenergic amines in treating bronchial congestion are well understood and supported by significant scientific evidence.

More about Adrenergic amines
More about Congestion (bronchial)

Other ingredients used for Congestion (bronchial)

Allspice
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alpha-pinene
waterhyssop
basil
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beta-pinene
black cumin
black currant
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Products containing Adrenergic amines

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