Evidence supporting the use of: Atractylone
For the health condition: Congestion (lymphatic)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Atractylone is a major sesquiterpene component isolated from the rhizome of Atractylodes macrocephala, a traditional Chinese medicinal herb. The use of Atractylodes (and by extension, atractylone) in supporting lymphatic congestion is primarily rooted in traditional Chinese medicine (TCM). In TCM, the herb is used to "strengthen the spleen" and "drain dampness," concepts believed to correspond to promoting fluid movement and addressing accumulations that could be likened to lymphatic congestion in modern terms. However, there is limited direct scientific research specifically on atractylone's effects on the lymphatic system. Most modern studies focus on its anti-inflammatory, immunomodulatory, and digestive benefits, rather than direct lymphatic action. Some animal and in vitro studies suggest atractylone may influence immune cell function and reduce inflammation, which could have indirect effects on lymphatic health, but this is not equivalent to direct evidence for treating lymphatic congestion. Thus, the use of atractylone for lymphatic congestion is supported by long-standing traditional use, with a small amount of indirect, low-level scientific evidence suggesting possible related benefits.

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