Evidence supporting the use of: Adrenergic amines
For the health condition: Congestion (sinus)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Adrenergic amines, such as phenylephrine and pseudoephedrine, are commonly used as decongestants to treat sinus congestion. The scientific basis for their use lies in their pharmacological action as sympathomimetic agents: they stimulate alpha-adrenergic receptors in the nasal mucosa, resulting in vasoconstriction. This vasoconstriction reduces blood flow to the nasal passages, thereby decreasing swelling and congestion of the mucous membranes. Clinical studies have demonstrated that oral and topical adrenergic amines can provide moderate relief of nasal congestion associated with conditions like allergic rhinitis and the common cold. For instance, pseudoephedrine has shown consistent efficacy in randomized controlled trials compared to placebo. However, the degree of symptom relief is often modest, and studies with phenylephrine have yielded mixed results, particularly for oral formulations, with some meta-analyses questioning its effectiveness.

Despite these limitations, adrenergic amines remain widely recommended in clinical practice and are included in treatment guidelines for acute and allergic rhinitis. Potential adverse effects, such as increased blood pressure, insomnia, and palpitations, limit their use in certain populations. Overall, there is solid scientific rationale and moderate-to-strong clinical evidence supporting the use of adrenergic amines for treating sinus congestion, though individual efficacy may vary.

More about Adrenergic amines
More about Congestion (sinus)

Other ingredients used for Congestion (sinus)

Aconite
Adrenergic amines
Agastache
Alantolactone
Allicin
Allium tuberosum
Allspice
Allyl isothiocyanate
Aloe vera
alpha-pinene
alpha-terpineol
alpinia galangal
Amor seco
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anise
Arisaema
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atractylone
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basil
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bee products
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betel
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bасора
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clove
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echinacea purpurea
Elder
elderberry
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Ephedra
ephedrine
eucalyptus
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fennel
ferula assafoetida
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Products containing Adrenergic amines

We currently have no products on Vitabase that contain this ingredient.