Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Congestion (sinus)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhizic acid, a major bioactive compound found in licorice root (Glycyrrhiza glabra), has a long history of use in traditional medicine systems, including Traditional Chinese Medicine (TCM) and Ayurveda. Licorice root preparations have been used for centuries to manage respiratory ailments such as cough, sore throat, and congestion. The rationale for its use in sinus congestion is largely based on its reputed anti-inflammatory and soothing properties, which are thought to help reduce mucous membrane irritation and swelling. While glycyrrhizic acid itself has demonstrated anti-inflammatory, antiviral, and immunomodulatory effects in preclinical studies, there is limited direct scientific evidence specifically validating its effectiveness for sinus congestion in humans. Most of the support for its use comes from traditional practices rather than robust clinical trials. Some herbal formulations containing licorice are used as adjuncts in respiratory tract infections, but well-designed studies focusing on glycyrrhizic acid for sinus congestion are lacking. Therefore, the evidence is primarily traditional and anecdotal, with a modest rating due to indirect support from its known biological activities.

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