Paris polyphylla, also known as "Chonglou" in traditional Chinese medicine (TCM), has a long history of medicinal use, primarily for its anti-inflammatory, analgesic, and detoxifying properties. Classical TCM texts and ethnobotanical sources describe its use to treat conditions such as snake bites, abscesses, sore throats, and various forms of swelling or inflammation. In some regional practices, Paris polyphylla is included in multi-herb formulas intended for respiratory issues, which may include symptoms such as congestion or sinusitis. However, these uses are based largely on traditional empirical knowledge rather than controlled scientific studies.

There is limited direct scientific research evaluating Paris polyphylla specifically for sinus congestion or related upper respiratory conditions. Most pharmacological studies have focused on its saponin compounds, which exhibit anti-inflammatory and antimicrobial effects in vitro and in animal models. These properties theoretically could be beneficial in conditions involving inflammation of the sinus mucosa, but there is no direct clinical evidence supporting its efficacy for sinus congestion in humans. Therefore, its use for this indication is primarily rooted in tradition rather than validated by rigorous scientific research.