Evidence supporting the use of: Black seed
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black seed (Nigella sativa) has a long history of use in traditional medicine, particularly in Middle Eastern and South Asian systems, for a wide range of health conditions, including cardiovascular ailments. The seeds and their oil are believed in traditional practice to strengthen the heart, improve circulation, and treat symptoms associated with heart failure. However, while there are some animal and laboratory studies suggesting that thymoquinone (the main active compound in black seed) may have cardioprotective, antioxidant, and antihypertensive properties, direct scientific evidence supporting its effectiveness specifically for congestive heart failure (CHF) in humans is limited and preliminary.

Most available scientific studies focus on risk factors related to heart disease, such as hypertension and lipid profiles, rather than on CHF itself. Clinical trials in humans addressing black seed’s efficacy in CHF are lacking. Thus, its use for this indication is primarily justified by traditional use rather than robust scientific validation. The evidence level is rated as 2, reflecting the presence of some supportive mechanistic or indirect evidence, but a lack of high-quality clinical trials specifically in CHF patients.

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