Evidence supporting the use of: Nigella seed
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nigella seed (Nigella sativa), also known as black seed or black cumin, has been studied in both animal models and limited human trials for its potential cardiovascular benefits, including applications in congestive heart failure (CHF). The primary bioactive constituent, thymoquinone, has demonstrated antioxidant, anti-inflammatory, and lipid-lowering effects in preclinical studies. Some animal studies have shown that Nigella sativa extract can improve cardiac function and reduce markers of oxidative stress in models of heart failure or cardiac injury. These effects are thought to be mediated by improved endothelial function, reduction in oxidative damage, and potential positive inotropic actions.

Human data, however, are sparse. A few small clinical studies have investigated Nigella sativa supplementation in patients with cardiovascular risk factors such as hypertension and dyslipidemia, showing modest improvements in blood pressure and cholesterol profiles. There is, however, a lack of robust, large-scale clinical trials directly evaluating its efficacy or safety in patients with established congestive heart failure. Most human evidence is indirect, focusing on risk factor modification rather than heart failure management per se.

In summary, while traditional use of Nigella sativa is extensive in various cultures for general health, scientific support for its use specifically in congestive heart failure is preliminary and based mainly on animal studies and indirect evidence from human trials addressing related cardiovascular risk factors. Its use in CHF cannot yet be recommended as evidence-based therapy.

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