Evidence supporting the use of: Osthole
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Osthole is a natural coumarin derivative extracted primarily from the fruit of Cnidium monnieri, a plant used in Traditional Chinese Medicine (TCM). Its use for cardiovascular conditions, including congestive heart failure (CHF), is grounded in traditional practices rather than robust scientific validation. In TCM, herbs containing osthole have been employed for a variety of indications, including promoting circulation and alleviating symptoms associated with heart "weakness" or insufficiency, which can be loosely correlated with modern definitions of heart failure.

Scientific studies directly investigating osthole for CHF in humans are lacking. Some preclinical studies in animal models and cell cultures suggest osthole may have cardioprotective effects, such as anti-inflammatory, antioxidant, and vasodilatory actions, as well as potential to inhibit cardiac hypertrophy and fibrosis. These mechanisms could theoretically benefit heart failure patients, but clinical data is absent. The evidence from traditional use and limited laboratory research does not yet meet modern standards for efficacy or safety in CHF.

In summary, osthole's use for congestive heart failure is primarily supported by traditional medicine knowledge. Current scientific evidence is preliminary and insufficient for clinical recommendations. More rigorous, controlled human studies are needed to validate any potential therapeutic role for osthole in CHF.

More about Osthole
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Products containing Osthole

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