Evidence supporting the use of: Polyphenols (various)
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols, a diverse group of naturally occurring compounds found in plants, have been investigated for their potential cardiovascular benefits, including in the context of congestive heart failure (CHF). Scientific studies, primarily preclinical and observational in nature, suggest that polyphenols—such as those found in green tea (catechins), cocoa (flavanols), red wine (resveratrol), and certain fruits—may exert cardioprotective effects. These effects are thought to stem from their antioxidant, anti-inflammatory, and endothelial function-improving properties. Some small clinical trials and animal studies indicate that polyphenols may improve endothelial function, reduce oxidative stress, and modulate signaling pathways involved in cardiac remodeling and dysfunction, all of which are relevant to CHF pathophysiology.

However, direct high-quality clinical evidence supporting the use of polyphenols as a treatment for established CHF is limited. Most of the available human data focus on surrogate markers (e.g., blood pressure, vascular function) or heart failure risk reduction, rather than on clinical endpoints in heart failure patients. Systematic reviews and meta-analyses call for larger, well-designed clinical trials to determine efficacy and safety in this specific population. Therefore, while there is a plausible biological rationale and some emerging human evidence, the overall strength of evidence remains low to moderate at this time.

More about polyphenols (various)
More about Congestive Heart Failure

Products containing polyphenols (various)

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