Evidence supporting the use of: Tanshinone
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tanshinone is a bioactive compound extracted from the root of Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb. Its use in the context of congestive heart failure (CHF) has both traditional roots and some scientific investigation. In traditional Chinese medicine, Danshen has been used for centuries to "invigorate blood" and treat cardiovascular disorders, including symptoms that would be classified as heart failure in modern medicine. Preclinical studies have demonstrated that Tanshinones exhibit cardioprotective effects, such as antioxidant, anti-inflammatory, anti-apoptotic, and vasodilatory activities. Several animal studies suggest that Tanshinone IIA, the most studied form, can improve cardiac function, reduce myocardial fibrosis, and modulate signaling pathways involved in heart failure pathology. Clinical evidence, however, is limited. A number of small-scale randomized controlled trials and meta-analyses, mostly conducted in China, have suggested that Tanshinone IIA (often as sodium tanshinone IIA sulfonate injection) may improve symptoms, cardiac function, and certain biomarkers in CHF patients, particularly when used alongside conventional therapy. However, these studies often suffer from methodological limitations, such as small sample sizes, short follow-up periods, and potential publication bias. As a result, while there is scientific investigation supporting its use, the overall quality and quantity of evidence remain low and insufficient for broad clinical recommendations outside of adjunctive use in certain contexts.

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