Evidence supporting the use of: Vitamin B1
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B1 (thiamine) is used in the management of congestive heart failure (CHF) based on both pathophysiological rationale and some clinical evidence. Thiamine is an essential cofactor in carbohydrate metabolism, and deficiency can lead to impaired cardiac function. Thiamine deficiency is not uncommon in patients with CHF, particularly those on chronic diuretic therapy (such as furosemide), which increases urinary thiamine excretion. Severe thiamine deficiency can cause “wet beriberi,” a condition marked by high-output cardiac failure, and supplementation reverses these symptoms.

Several small clinical studies and case reports have investigated thiamine supplementation in CHF. Some randomized controlled trials have demonstrated modest improvements in left ventricular ejection fraction and symptomatic status in CHF patients given thiamine supplements, particularly when deficiency is present. However, these studies tend to be small and short-term, and the degree of benefit observed is variable. Systematic reviews conclude that while thiamine supplementation appears safe and may benefit selected patients (especially those with proven deficiency), robust evidence from large, long-term trials is lacking. Thus, while there is scientific rationale and limited clinical evidence supporting thiamine use in CHF—especially in those at risk for deficiency—the overall quality and quantity of evidence is modest.

More about Vitamin B1
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