Evidence supporting the use of: Vitamin B1 (thiamin pyrophosphate)
For the health condition: Congestive Heart Failure

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B1 (thiamin), specifically in its active form thiamin pyrophosphate, has some scientific rationale for use in patients with congestive heart failure (CHF), though the evidence is limited and not part of standard guideline-directed therapy. Thiamin deficiency can occur in CHF patients, especially those receiving chronic loop diuretic therapy (such as furosemide), which increases urinary thiamin excretion. Thiamin is essential for myocardial energy metabolism, and deficiency may worsen cardiac function.

Several small clinical studies and case reports have documented improvement in left ventricular ejection fraction, cardiac output, and symptoms in CHF patients after thiamin supplementation, particularly in those identified as deficient. Randomized controlled trials (RCTs), however, are limited in size and methodological rigor. A 2013 systematic review (Schoenenberger et al.) concluded that while some small studies showed modest improvements, the overall quality of evidence is low and further large-scale trials are needed.

Currently, thiamin supplementation is sometimes considered for CHF patients at high risk of deficiency or with documented low thiamin levels. However, it is not universally recommended for all CHF patients. Thus, the use of thiamin/TPP in CHF is supported by plausible mechanisms and some preliminary studies, but robust scientific validation is lacking, justifying a moderate-low evidence rating.

More about Vitamin B1 (thiamin pyrophosphate)
More about Congestive Heart Failure

Other health conditions supported by Vitamin B1 (thiamin pyrophosphate)

Alcoholism
Congestive Heart Failure
Diabetes
Fatigue
Heart (weakness)
Peripheral Neuropathy

Products containing Vitamin B1 (thiamin pyrophosphate)

We currently have no products on Vitabase that contain this ingredient.