Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoperoxidase is an enzyme naturally present in various body fluids, including tears, and is a key component of the eye's antimicrobial defense system. Its use in supporting or treating conjunctivitis is primarily justified by scientific rationale based on its biochemical properties, although direct clinical trial evidence in humans is limited, resulting in a moderate evidence rating of 2 out of 5.

Lactoperoxidase functions by catalyzing the oxidation of thiocyanate ions in the presence of hydrogen peroxide to produce hypothiocyanite, a compound with broad-spectrum antimicrobial activity. Several in vitro studies have shown that lactoperoxidase can inhibit the growth of common ocular pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. Animal model studies and ex vivo experiments suggest that supplementing the natural lactoperoxidase system can reduce the microbial load on the ocular surface and may help in preventing or limiting infections such as conjunctivitis.

However, robust clinical trials in humans specifically evaluating the efficacy of lactoperoxidase-containing eye drops or formulations for the treatment of conjunctivitis are lacking. Most available data are preclinical or theoretical, and some over-the-counter products incorporate lactoperoxidase as a supportive agent based on its natural role in ocular immunity rather than direct clinical evidence.

In summary, the use of lactoperoxidase for conjunctivitis is scientifically rational and supported by laboratory and animal data, but there is insufficient high-quality clinical evidence to fully validate its therapeutic effectiveness in humans.

More about lactoperoxidase
More about Conjunctivitis

Other ingredients used for Conjunctivitis

Other health conditions supported by lactoperoxidase

Products containing lactoperoxidase

Metagenics Probioplex® Intensive Care Powder