Evidence supporting the use of: Glycerol polymers
For the health condition: Constipation (adults)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glycerol polymers, most commonly in the form of glycerol suppositories, are scientifically validated for use in treating constipation in adults. Glycerol acts as an osmotic laxative: it draws water into the colon, which softens stool and stimulates peristalsis, thus facilitating bowel movements. Numerous clinical studies and clinical guidelines (such as those from the American Society of Colon and Rectal Surgeons and the National Institute for Health and Care Excellence) endorse the use of glycerol suppositories for occasional constipation, particularly when oral laxatives are ineffective or unsuitable.

The mechanism is well-understood: glycerol is poorly absorbed rectally and exerts its effect locally by increasing the water content in the stool and lubricating the rectal mucosa. This dual action helps ease the passage of feces. Systematic reviews and randomized controlled trials demonstrate that glycerol suppositories are effective, fast-acting (typically within 15-60 minutes), and generally safe, although they may cause mild local irritation in some individuals.

While there are other forms of osmotic laxatives (like polyethylene glycol), glycerol suppositories are specifically recommended for rapid relief of constipation, and their use is supported by decades of clinical use and scientific research. Thus, the use of glycerol polymers for constipation in adults is well-supported by scientific evidence.

More about Glycerol polymers
More about Constipation (adults)

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Products containing Glycerol polymers

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