Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Mannitol is scientifically validated for use in the management of constipation in adults, mainly as an osmotic laxative. Mannitol is a sugar alcohol that is poorly absorbed in the gastrointestinal tract. When administered orally, it remains in the lumen of the intestine, where it exerts an osmotic effect, drawing water into the colon. This increased water content softens stools and stimulates bowel movements, thereby alleviating constipation.

Several clinical studies and pharmacological reviews support the efficacy of mannitol as a laxative. Mannitol is included in pharmacopoeias (for example, the European Pharmacopoeia) as a recognized osmotic laxative. It is often used in hospital settings for bowel preparation before diagnostic procedures or surgery, and occasionally for the management of chronic constipation when other agents are unsuitable or ineffective. According to a review in the World Journal of Gastroenterology (2015), osmotic laxatives such as mannitol are effective and generally well-tolerated for short-term relief of constipation.

However, mannitol can cause side effects such as bloating, flatulence, and abdominal cramping, and excessive use can lead to electrolyte disturbances. It is less commonly used than other osmotic laxatives like lactulose or polyethylene glycol, but remains a valid option, particularly where these alternatives are not available or tolerated.

In summary, mannitol’s use for constipation is well-supported by both clinical use and scientific literature, justifying a high evidence rating.

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More about Constipation (adults)

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