Evidence supporting the use of: Sennosides
For the health condition: Constipation (adults)
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Sennosides, the active compounds found in senna plants (Senna alexandrina), are well-established stimulant laxatives commonly used to treat constipation in adults. Their use is strongly supported by scientific evidence. Sennosides work by irritating the lining of the bowel, which stimulates intestinal motility and alters water and electrolyte secretion, resulting in a laxative effect. Multiple randomized controlled trials and systematic reviews have confirmed their efficacy in promoting bowel movements and relieving constipation, particularly in cases of short-term or occasional constipation.
Clinical guidelines, such as those from the American Gastroenterological Association and the National Institute for Health and Care Excellence (NICE), endorse the use of stimulant laxatives like sennosides for the management of constipation when other measures (such as increased fiber or osmotic laxatives) are insufficient. Sennosides are available over-the-counter in various formulations and are included in the World Health Organization's List of Essential Medicines. While effective, sennosides are generally recommended for short-term use due to the potential for side effects such as abdominal cramping, diarrhea, and, with prolonged use, electrolyte imbalances or dependency.
In summary, sennosides are scientifically validated and widely recommended for the short-term treatment of constipation in adults, with robust evidence supporting their safety and efficacy when used as directed.
Other ingredients used for Constipation (adults)
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apricot
asparagus
bacillus coagulans
bacillus subtilis
barley
basil
beet
myrobalan
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
bio ecolian (proprietary)
black cumin
black currant
black pepper
radish
blackberry
broccoli
bupleurum falcatum
burdock
bасора
carrot
cauliflower
celery
chamomile
chia seed
chicory
chlorella
cinnamon
clove
coconut milk
cowage seed
cucumber
turmeric
d-sorbitol
dandelion
dog rose
melon
fennel
fiber blend (proprietary)
flaxseed
fructooligosaccharides (FOS)
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
ginger
ginseng
gooseberry
green banana
onion
green tea
greens blend (proprietary)
guar gum
cellulose
Indian gum arabic tree
Indian tinospora
inulin
isomalto-oligosaccharide
jujube
kale
kudzu
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus casei
lactobacillus fermentum
lactobacillus gasseri
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lemon
licorice root
lovage
magnesium
mango
mannitol
moringa
nettle
oat
ophiopogon root
orange
parsley
pear
pectin
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pineapple
plantain
plum fruit
pomegranate
potato starch
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butyric acid
prune
psyllium
pumpkin
quail egg
raspberry
redcurrant
rhizome
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sphaeranthus indicus
spinach
streptococcus thermophilus
thyme
tomato
triphala
almond fruit
vegetable and fruit blend (proprietary)
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seaweed
watercress
watermelon
xylooligosaccharides
cascara sagrada
tangerine
cardamom
atractylodes
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mugwort
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neem tree
nut grass
alpinia galangal
anise
punarnava
tinospora cordifolia
caesalpinia crista
swertia
peony
lingusticum wallichii
morus
lemongrass
sunflower
root tuber
flowering quince
dioscorea
ganoderma
sweet flag
hyacinth bean
morinda
trichosanthes
zanthoxylum
polyphenols
caraway
purslane
senna
aster root
peach
noni
nopal
goji berry
paw paw
millet seed
algae
indigo leaves
enzymes blend (proprietary)
cayenne pepper
soursop
sea salt
Agar
Apple Cider Vinegar
Actinidin
Agastache
Anthraquinone
Ardisia
Angelica
acacia
Auricularia
Amomum
Avocado
Alexandrian senna
Aloin
Aerva lanata
Asam gelugor
Asteracea
Arabinoxylan
Allium tuberosum
Amor seco
Atractylone
Black Seed
Bifidobacterium
Buttermilk
Bifidobacterium adolescentis
Baliospermum
Bidens pilosa
Broussonetia
Brassica
Bishop's Weed
Belleric myrobalan
Bran
Butea monosperma
Bitter Grass
Bael
Bean
Butternut
Baccharoides anthelmintica
black salt
Bifidobacterium animalis
Bee products
Bombax
Borassus Palm
Borassus aethiopum
Bitter principals
Bacteria
banana
Baobab
Bifidobacteria
Bacillus
Bassia scoparia
Boerhavia diffusa
Bottle gourd
Borneol
Cumin
Coconut
Chinese Silkvine
Curry leaf
California chia
Cinnamomum
Cascaroside
Cucurbita
coconut oil
Coriander
Cactus
Cynomorium
Cape Aloe
Citrus
Cantaloupe
Cereal grass
Chinese Raisintree
Cruciferous
Cyclanthera pedata
Curcumen
Chard
Chenopodium
Curcuma
Cabbage
Chirata
Clostridium butyricum
Castor Oil
Carthamus
Colocynth
Celosia
Currant
Chondrus
Dianthus
Dextrin
Dragonhead
Dianthrone
Dwarf Morning Glory
Date
Dulse
Emblicanin
Endive
Embelia
Emodin
Fig
Fiber
Flavonoids
Galangal
Lotus
Molasses
Phosphate Salt
Prickly Pear Cactus
Quince
Rose
Rhubarb
Sumac
Vinegar
Wheat
Zucchini
Other health conditions supported by Sennosides
Colon (atonic)Constipation (adults)
Constipation (children)