Sorbitol ester, more commonly referred to simply as "sorbitol," is widely recognized in clinical practice as an osmotic laxative for the treatment of constipation in adults. Sorbitol is a sugar alcohol that exerts its laxative effect primarily by drawing water into the large intestine, thereby softening stools and stimulating bowel movements. Its use is supported by several clinical studies and is recommended in treatment guidelines for occasional constipation.

The evidence base includes randomized controlled trials comparing sorbitol to other laxatives, such as lactulose, showing comparable efficacy in increasing stool frequency and improving stool consistency. The mechanism of action is well understood: sorbitol is poorly absorbed in the gastrointestinal tract, which leads to its osmotic activity. It is commonly administered as a solution, and its use is documented in pharmacological references and medical guidelines for adults with constipation, particularly when dietary and lifestyle measures are insufficient.

Side effects are generally mild, with the most common being abdominal discomfort and flatulence due to fermentation by colonic bacteria. Nonetheless, its safety profile is considered favorable, especially for short-term use. Overall, the use of sorbitol (and its esters, though less common) as a laxative is backed by scientific research, and it is an established therapy in both outpatient and inpatient settings.