Aloe macroclada, a species of aloe native to Madagascar, has been traditionally used for a variety of medicinal purposes, including as a laxative to treat constipation. In Malagasy traditional medicine, preparations made from the leaves or latex of the plant are administered to promote bowel movements in both adults and children. The primary basis for its use in constipation is the presence of anthraquinone glycosides, compounds that are also found in other aloe species and are known for their stimulant laxative effects. These substances act by increasing intestinal water content and stimulating peristalsis, which helps relieve constipation.

However, while the traditional use is well-documented in ethnobotanical literature, there is a lack of clinical trials or rigorous scientific studies specifically evaluating the effectiveness and safety of Aloe macroclada for treating constipation in children. Most of the available evidence is anecdotal or based on reports from traditional healers. Furthermore, concerns exist regarding the safety of anthraquinone-containing laxatives in children, as they can cause abdominal cramping, dehydration, and electrolyte imbalances if used improperly.

In summary, the use of Aloe macroclada for constipation in children is justified by traditional practice rather than scientific validation, and caution should be exercised due to the potential risks associated with its bioactive compounds.