Evidence supporting the use of: Aloin
For the health condition: Constipation (children)
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Aloin, a compound found in the latex of Aloe species (especially Aloe vera and Aloe ferox), has a long history of traditional use as a stimulant laxative to treat constipation, including in children. Historical records and ethnobotanical sources indicate its use in folk medicine dating back centuries, where aloe latex preparations were administered to relieve bowel irregularity. Aloin acts by stimulating intestinal peristalsis and reducing water absorption in the colon, leading to softer stools and increased bowel movements.
However, while traditional use is well documented, scientific studies specifically evaluating the safety and efficacy of aloin (or aloe latex) in children are limited. Some clinical trials in adults have demonstrated laxative effects, but concerns about safety (such as potential electrolyte imbalance, abdominal cramping, and even carcinogenicity with long-term use) have led regulatory agencies, including the FDA, to restrict or warn against the use of aloe-containing laxatives.
In summary, while the use of aloin for childhood constipation is justified by traditional practice, there is a lack of robust, high-quality clinical data supporting its safety and efficacy in pediatric populations. Modern guidelines generally do not recommend aloe-based laxatives for children due to these safety concerns.
Other ingredients used for Constipation (children)
2'-FucosyllactoseAgar
Alexandrian senna
Allium tuberosum
Almond fruit
Aloe vera
Aloin
alpinia galangal
Amomum
Amor seco
anise
anthraquinone
apple
Appleblossom Cassia
apricot
arabinoxylan
Ardisia
Asam gelugor
Asteraceae
atractylodes
atractylone
Bacillus
bacillus coagulans
bacteria
bael
bamboo
basil
Bassia scoparia
bee products
beet
belleric myrobalan
Bidens pilosa
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bio ecolian (proprietary)
bishop\'s weed
bitter grass
black salt
black seed
blackberry
blackboard tree
blueberry
Bombax
borassus palm
borneol
bottle gourd
bran
Broussonetia
butternut
bасора
cabbage
cactus
cantaloupe
carrot
cascara sagrada
cascaroside
castor oil
Celosia
chamomile
Chenopodium
chicory
chirata
Chondrus
cinnamon
Citrus
citrus sinensis (proprietary)
Clostridium butyricum
coconut
coconut milk
Coptis chinensis
cowage seed
cucumber
Curcuma
currant
curry leaf
Cyclanthera pedata
Cynomorium
date
dianthrone
dioscorea
dodder
Eclipta
fennel
fiber
fiber blend (proprietary)
fig
Frangula
fructan
fructooligosaccharides (FOS)
fruit
fruit and vegetable blend (proprietary)
galactomannan
galactooligosaccharides
Galangal
Glucofrangulin
grape
green banana
guar gum
Guava
honey
hydroxyanthracene derivatives
Hydroxycellulose
Hygrophila
Indian bael
Indian kinotree
Indian tinospora
indigo leaves
inulin
isomalto-oligosaccharide
Jalap
jujube
jungli-bean
karaya gum
Kefir
lactitol
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus gasseri
Lactobacillus kefiri
Lactobacillus pentosus
Lactobacillus reuteri
Lactococcus rhamnosus
lemon
ligustilides
lodhtree
long pepper
luffa
Methylcellulose
Moringa
Mucilage
Mugwort
Myrobalan
Nettle
nut grass
Nutmeg
Nymphaea nouchali
Oligosaccharides
Operculina turpethum
Ophiopogon
orange
Oryza sativa
Osmanthus
Palmyra
papaya
peach
pear
Phaeophyceae
phellodendron amurense
Phyllanthus
pineapple
Piper nigrum
Piper retrofractum
Plantago
plum fruit
Polygonum
polyphenols
polysaccharides
pomegranate
prebiotic blend (proprietary)
probiotics
prune
psyllium
pumpkin
punarnava
Pyrrosia
raspberry
Rhamnus nakaharai
rhizome
rhubarb
ricinoleic acid
root tuber
Rubiaceae
seaweed
senna
Sennosides
Sesbania
Sete sangrias
Sicklepod
Slippery Elm
slippery elm bark
Solanum indicum
soursop
spinach
squawvine
streptococcus thermophilus
Sulfated polysaccharide
sweet flag
Tamaricaceae
Tamarind
Tea
Triphala
turmeric
vegetable and fruit blend (proprietary)
Watermelon
Wax Gourd
Wheat
Yacon
Yerba buena
Zedoary
Zingerone
Zucchini
Other health conditions supported by Aloin
Constipation (adults)Constipation (children)
Digestion (poor)
Inflammation