Evidence supporting the use of: Hydroxycellulose
For the health condition: Constipation (children)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Hydroxycellulose, also known as hydroxyethylcellulose or hydroxypropylcellulose, is a chemically modified cellulose derivative commonly used as a bulk-forming laxative. Its use in treating constipation, including in children, is based on its ability to absorb water and increase stool bulk, promoting peristalsis and facilitating bowel movements. The scientific validation for hydroxycellulose's use stems from its similarity to other well-established bulk-forming agents such as methylcellulose and psyllium.
Clinical guidelines and studies on pediatric constipation generally recommend bulk-forming laxatives as one of the first-line non-pharmacologic treatments, particularly for mild cases. While most large-scale studies and regulatory approvals focus on agents like methylcellulose and psyllium, hydroxycellulose functions via the same mechanism and is occasionally referenced in clinical resources as an alternative. However, direct high-quality clinical trial evidence specific to hydroxycellulose in children is limited, and much of its use is extrapolated from adult data and from studies on related cellulose derivatives.
Safety profiles for hydroxycellulose are favorable, with minimal systemic absorption and generally mild gastrointestinal side effects. As with all bulk-forming agents, adequate hydration is essential to prevent obstruction. Overall, the supporting evidence for its use in pediatric constipation is moderate (rated 3/5), primarily based on its well-understood mechanism and analogies to better-studied agents, rather than extensive pediatric-specific clinical trials.
More about Hydroxycellulose
More about Constipation (children)
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