Evidence supporting the use of: Magnesium citrate oxide
For the health condition: Constipation (children)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Magnesium oxide is commonly used as an osmotic laxative for the treatment of constipation, including in pediatric populations. The use of magnesium salts for constipation has both historical and scientific backing, but the evidence for magnesium oxide specifically is substantial. Magnesium oxide draws water into the intestines, softening stool and promoting bowel movements. Several clinical studies and guidelines, such as those from the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), support the use of magnesium oxide in children with functional constipation. Evidence suggests it is effective and generally safe, especially for short-term use, though dosing must be carefully managed to avoid hypermagnesemia, particularly in children with renal impairment. While polyethylene glycol (PEG) is often preferred as a first-line agent due to greater evidence and fewer side effects, magnesium oxide is a recognized and widely used alternative, particularly in Japan and some other regions. Its use is supported by randomized controlled trials and clinical practice guidelines, giving it a high evidence rating. However, "magnesium citrate oxide" is not a standard pharmaceutical term; magnesium oxide and magnesium citrate are distinct compounds, both used as laxatives, but the evidence here pertains specifically to magnesium oxide.
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Other health conditions supported by Magnesium citrate oxide
Constipation (children)Sleep (restless and disturbed)