Methyl cellulose is a semi-synthetic, non-digestible fiber that acts as a bulk-forming laxative. Its use for treating constipation, including in children, is scientifically validated and supported by several clinical guidelines and studies. Methyl cellulose works by absorbing water in the intestines, increasing stool bulk and moisture, which in turn stimulates peristalsis and promotes bowel movements. This mechanism is similar to other bulk-forming agents like psyllium and polycarbophil.

The American Academy of Pediatrics and other pediatric gastroenterology references list methyl cellulose as an option for the management of functional constipation in children. While the bulk of high-quality clinical trials focus on adults, there is evidence from smaller pediatric studies and expert consensus that methyl cellulose is both effective and well tolerated in children for this indication. Adverse effects are generally mild and include bloating or gas, and it must be taken with adequate fluids to prevent obstruction.

In summary, the use of methyl cellulose for pediatric constipation is grounded in scientific evidence and clinical experience, earning a rating of 4 out of 5. The evidence base is strong but not as extensive in children as in adults, which prevents a perfect score.