Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Sennosides are anthraquinone glycosides derived from the senna plant (Senna alexandrina), and they are widely recognized as stimulant laxatives. Their use in treating constipation, including in children, is supported by clinical evidence and established guidelines. Sennosides act by stimulating colonic motility and altering water and electrolyte secretion in the colon, which leads to bowel movements typically within 6–12 hours after oral administration.

Multiple clinical studies and systematic reviews have evaluated the efficacy and safety of sennosides for pediatric constipation. The North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) both include stimulant laxatives such as sennosides in their guidelines for the management of functional constipation in children, typically as a second-line agent after osmotic laxatives like polyethylene glycol (PEG) or lactulose. Sennosides are considered effective for short-term use when rapid relief is needed or when other agents are insufficient.

While sennosides are effective, their use in children should be carefully monitored due to the potential for abdominal cramping, electrolyte imbalance, and dependence with prolonged use. Overall, the evidence base supporting sennosides for pediatric constipation is robust, with randomized controlled trials and expert consensus, although they are not typically recommended as a first-line therapy.

More about Sennoside
More about Constipation (children)

Other ingredients used for Constipation (children)

2'-Fucosyllactose
aloe vera
apple
apricot
bacillus coagulans
bamboo
basil
beet
myrobalan
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
bio ecolian (proprietary)
blackberry
blueberry
bасора
carrot
chamomile
chicory
cinnamon
citrus sinensis (proprietary)
coconut milk
Coptis chinensis
cowage seed
cucumber
turmeric
d-sorbitol
fennel
fiber blend (proprietary)
fructooligosaccharides (FOS)
fruit and vegetable blend (proprietary)
grape
green banana
guar gum
cellulose
Indian tinospora
inulin
isomalto-oligosaccharide
jujube
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus gasseri
lactobacillus reuteri
lemon
mannitol
moringa
nettle
orange
pear
phellodendron amurense
pineapple
plum fruit
pomegranate
potato starch
prebiotic blend (proprietary)
prune
psyllium
pumpkin
raspberry
rhizome
slippery elm bark
sorbitol
spinach
streptococcus thermophilus
tomato
triphala
almond fruit
vegetable and fruit blend (proprietary)
seaweed
watermelon
squawvine
cascara sagrada
tangerine
atractylodes
papaya
mugwort
Indian bael
nut grass
alpinia galangal
anise
punarnava
blackboard tree
root tuber
dioscorea
dodder
sweet flag
polyphenols
senna
peach
indigo leaves
soursop
Agar
Anthraquinone
Ardisia
Amomum
Alexandrian senna
Aloin
Appleblossom Cassia
Asam gelugor
Asteracea
Arabinoxylan
Allium tuberosum
Amor seco
Atractylone
Black Seed
Bifidobacterium
Bifidobacterium adolescentis
Bidens pilosa
Broussonetia
Bishop's Weed
Belleric myrobalan
Bran
Bitter Grass
Bael
Butternut
black salt
Bifidobacterium animalis
Bee products
Bombax
Borassus Palm
Bacteria
Bifidobacteria
Bacillus
Bassia scoparia
Bottle gourd
Borneol
Coconut
Curry leaf
Cascaroside
Cactus
Cynomorium
Citrus
Cantaloupe
Cyclanthera pedata
Chenopodium
Curcuma
Cabbage
Chirata
Clostridium butyricum
Castor Oil
Celosia
Currant
Chondrus
Dianthrone
Date
Eclipta
Fig
Fiber
Galangal
Phosphate Salt
Rhubarb
Wheat
Zucchini

Other health conditions supported by Sennoside

Colon (atonic)
Colon (spastic)
Constipation (adults)
Constipation (children)
Hemorrhoids

Products containing Sennoside

We currently have no products on Vitabase that contain this ingredient.