Evidence supporting the use of: Albumin
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Albumin is a plasma protein often used in clinical practice to support patients during convalescence, especially in cases involving hypoalbuminemia (low serum albumin), severe illness, or recovery from major surgery or trauma. The scientific rationale for its use is based on its role in maintaining plasma oncotic pressure, transporting hormones, drugs, and other substances, and modulating fluid balance. Clinical studies have evaluated albumin infusions in patients recovering from critical illness, sepsis, or burns, where hypoalbuminemia is associated with poorer outcomes and delayed recovery.

However, the evidence for routine use of albumin in general convalescence (i.e., recovery from illness or surgery without clear hypoalbuminemia or fluid imbalance) is limited. Systematic reviews, such as those by the Cochrane Collaboration, have shown that albumin does not significantly improve mortality in critically ill patients compared to crystalloids. Its use may be beneficial in specific situations like liver cirrhosis with ascites, nephrotic syndrome, or severe burns, but not in routine convalescence. Most guidelines recommend albumin only when there is a clear clinical indication, such as persistent hypoalbuminemia with symptoms or refractory edema, rather than as a general restorative agent.

In summary, while there is a scientific basis for its use in selected cases during convalescence, the evidence supporting routine use is moderate (rated 3/5), and its benefit is context-specific rather than universal.

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Products containing Albumin

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