Evidence supporting the use of: Alpha-Ketoglutarate
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Ketoglutarate (AKG) is an intermediate in the Krebs cycle and has been explored for its potential role in supporting recovery during convalescence, particularly in situations involving muscle wasting, surgery, trauma, or illness. The scientific rationale for its use is based on AKG’s involvement in amino acid metabolism and energy production. Several clinical studies have investigated AKG or its salts (such as ornithine alpha-ketoglutarate, OAKG) in hospital settings, especially in patients recovering from surgery or severe illness.

Some trials suggest that supplementation with AKG or related compounds may help reduce protein catabolism, support nitrogen balance, and possibly improve wound healing and recovery rates. For instance, OAKG has shown some benefit in reducing muscle breakdown and improving markers of nutritional status in catabolic patients. However, the majority of studies are relatively small, sometimes with mixed results, and often use AKG in combination with other amino acids or nutrients, making it difficult to isolate the specific effects of AKG.

Overall, while there is some scientific basis and preliminary clinical evidence supporting the use of alpha-ketoglutarate in convalescence—particularly for counteracting catabolism and supporting recovery—the quality and quantity of evidence are limited. Larger, more rigorous trials are needed to confirm these effects, and its routine use in convalescence is not yet a universally accepted standard of care.

More about Alpha-Ketoglutarate
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