Evidence supporting the use of: Alpha-ketoglutarate (AKG)
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-ketoglutarate (AKG) has some scientific rationale for use during convalescence, though the supporting evidence is modest and largely preliminary. AKG is a key intermediate in the Krebs cycle, involved in cellular energy production and amino acid metabolism. During periods of illness, injury, or recovery (convalescence), metabolic demands may increase, and muscle wasting or negative nitrogen balance can occur. Some studies have explored AKG supplementation, often as part of amino acid salts (such as ornithine alpha-ketoglutarate, OKG), to potentially improve nitrogen retention, reduce protein breakdown, and support recovery, especially in catabolic states. Clinical investigations in surgical and critically ill patients suggest that OKG supplementation may help preserve muscle mass, enhance wound healing, and reduce hospital stays. The proposed mechanisms include providing anaplerotic substrates for the TCA cycle, supporting glutamine and arginine synthesis, and modulating immune responses. However, high-quality, large-scale randomized controlled trials are limited, and results are somewhat inconsistent, with some studies showing benefit and others showing minimal or no effect. AKG is not a standard-of-care intervention for convalescence, but its use is supported by a plausible scientific rationale and some initial clinical evidence, particularly in specialized medical nutrition settings. Further research is needed to confirm efficacy, optimal dosing, and patient selection. Overall, while not purely traditional, AKG’s use in convalescence is rooted in metabolic science, but currently supported by only moderate-quality evidence.

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