Evidence supporting the use of: Branched-chain amino acids
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—are essential amino acids commonly used to support convalescence, particularly in individuals recovering from illness, surgery, or trauma that leads to muscle wasting or increased protein requirements. Scientific evidence indicates that BCAAs play a critical role in muscle protein synthesis and reducing muscle breakdown, which are key concerns during periods of recovery.

Multiple clinical studies have demonstrated that BCAA supplementation can help preserve lean body mass in patients undergoing prolonged bed rest, recovering from surgery, or experiencing chronic illnesses such as cancer or liver disease. For example, BCAA-enriched formulas are frequently used in hospital settings for patients with hepatic encephalopathy or severe burns, as they help support nitrogen balance and muscle metabolism. A 2017 systematic review in Clinical Nutrition highlighted that BCAA supplementation significantly reduced muscle wasting in patients with liver cirrhosis and improved recovery parameters in post-operative and trauma patients.

However, while the mechanistic rationale and some clinical data are supportive, not all trials have shown clear-cut benefits in otherwise healthy individuals or in all patient populations, and the overall effect sizes can be modest. Thus, BCAA supplementation during convalescence is scientifically justified in specific clinical contexts where muscle loss is a significant risk, though further research is needed to refine guidelines and identify optimal candidates for supplementation.

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