Free form amino acids are individual amino acids not bound in protein chains, allowing for rapid absorption and utilization by the body. Their use during convalescence—recovery from illness, injury, or surgery—has some scientific basis. During convalescence, the body's demand for protein and specific amino acids often rises due to increased tissue repair, immune activity, and metabolic needs. Supplementing with free form amino acids can help address temporary protein deficiencies or impaired digestion, which are common in weakened or bedridden patients.

Clinical studies have shown that supplementation with essential amino acids or specific formulations (such as branched-chain amino acids) may promote muscle protein synthesis, improve nitrogen balance, and support healing, especially in elderly, malnourished, or post-surgical patients. For example, a 2017 review in Clinical Nutrition concluded that essential amino acid mixtures could enhance recovery and preserve muscle mass during periods of immobilization. However, much of the evidence comes from relatively small trials or studies on specific populations (e.g., elderly, those with chronic disease), rather than large-scale randomized controlled trials in the general convalescent population.

In summary, there is moderate scientific support for the use of free form amino acids to aid recovery during convalescence, particularly where protein intake or absorption is compromised, though more robust clinical trials are needed for definitive recommendations.