Evidence supporting the use of: Glutamine
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glutamine is an amino acid that plays a key role in various physiological processes, including immune function, gut integrity, and protein synthesis. Its use as a supplement during convalescence—recovery from illness, surgery, or trauma—is primarily based on scientific investigation rather than tradition. Several clinical studies have evaluated glutamine supplementation in hospitalized patients, particularly those experiencing severe stress (e.g., after surgery, trauma, burns, or critical illness). Research has shown that glutamine levels can decrease during periods of physiological stress, and supplementation may help restore immune competence, reduce infection rates, and preserve gut mucosal integrity. Some randomized controlled trials have reported that glutamine supplementation reduces hospital stay length and infection rates in certain populations, such as patients in intensive care or those undergoing major surgery. However, meta-analyses and systematic reviews highlight variability in outcomes, depending on patient populations and study design. The evidence is stronger for specific groups (e.g., critically ill or surgical patients) and less robust for general convalescence or less severe illness. Current clinical guidelines often recommend considering glutamine supplementation in selected, high-risk populations but not for routine use in all recovering patients. In summary, scientific evidence supports the role of glutamine in specific convalescent contexts, but the strength of evidence is moderate and not universal.

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Products containing Glutamine

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