Evidence supporting the use of: Glutamine (various)
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glutamine is an amino acid that has been studied for its role in supporting recovery during periods of convalescence, particularly after injury, surgery, or illness. During severe physiological stress, such as trauma or infection, glutamine becomes a "conditionally essential" amino acid, as the body's demand exceeds its ability to synthesize it. Scientific evidence shows that glutamine is important for immune cell function, maintaining the integrity of the gut mucosa, and nitrogen transport.

Clinical trials have investigated glutamine supplementation in hospitalized and critically ill patients, with mixed results. Some studies report that glutamine supplementation can help reduce infection rates, support gut barrier function, and shorten hospital stays, especially in patients receiving parenteral nutrition. However, large meta-analyses have shown variable results, with some failing to demonstrate significant benefits in mortality or other primary outcomes, particularly in general ICU populations. Nonetheless, glutamine continues to be used in specific clinical contexts, such as burns, trauma, and major surgery, where certain studies support its role in reducing complications and supporting recovery.

In summary, there is moderate scientific evidence for the use of glutamine in supporting convalescence, particularly in patients with increased metabolic demand or compromised immune/gut function. While not universally recommended for all patients, its use is justified in select clinical scenarios based on current research.

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