Evidence supporting the use of: Hydroxymethylbutyrate
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hydroxymethylbutyrate (HMB), a metabolite of the amino acid leucine, has been investigated for its role in supporting muscle mass and function during periods of convalescence, especially in individuals experiencing muscle wasting due to illness, injury, or prolonged bed rest. Scientific studies have demonstrated that HMB supplementation can reduce muscle protein breakdown and promote muscle protein synthesis, mechanisms important for preserving lean body mass during recovery. Randomized controlled trials in elderly patients, individuals recovering from surgery, and those subjected to immobilization have shown that HMB can attenuate muscle loss, improve functional outcomes, and sometimes enhance strength gains compared to placebo. However, the magnitude of effect varies, and not all studies have found significant benefits. The evidence is stronger in populations at risk for muscle wasting (e.g., elderly, malnourished, or critically ill patients) than in healthy adults. Clinical guidelines and expert reviews generally acknowledge HMB as a potentially useful adjunct in managing muscle loss during convalescence, though it is typically recommended as part of a broader nutritional and rehabilitation strategy rather than as a sole intervention. Overall, while scientific validation exists, the evidence is moderate in quality and consistency, warranting a rating of 3 out of 5.

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