Evidence supporting the use of: Leucine
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Leucine is an essential branched-chain amino acid (BCAA) that plays a critical role in muscle protein synthesis and metabolic recovery. Scientific evidence supports its use in convalescence—especially after periods of illness, surgery, or trauma that involve muscle wasting or increased protein breakdown. Leucine activates the mTOR pathway, a key regulator of protein synthesis in skeletal muscle. Clinical studies have shown that supplementation with leucine, either alone or as part of BCAA or high-protein formulas, can promote muscle protein synthesis, reduce the loss of lean body mass, and improve recovery outcomes in elderly or hospitalized patients undergoing rehabilitation or recovering from illness.

For example, randomized controlled trials in older adults and post-surgical patients have demonstrated that leucine-enriched supplementation can enhance muscle mass retention and functional recovery compared to standard nutritional support. Additionally, guidelines for nutritional support in clinical settings often recommend increased protein and leucine intake during recovery phases. However, while the mechanistic rationale and some clinical studies are strong, the overall quality and consistency of clinical evidence varies, with some trials showing modest or no benefit on functional outcomes. Thus, the evidence is considered moderate (rated 3 out of 5), with further high-quality research needed to solidify specific protocols and long-term benefits.

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Products containing Leucine

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