Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Liquid liver fractions, derived from animal liver (commonly bovine), have been used both traditionally and in clinical settings to support convalescence, which refers to recovery after illness or surgery. The rationale is largely based on the liver’s nutrient density—particularly its rich content of heme iron, vitamin B12, folic acid, protein, and other micronutrients essential for hematopoiesis and tissue repair. Historically, liver extracts were used in the early 20th century to treat pernicious anemia before vitamin B12 was isolated. Several studies from the mid-1900s demonstrated that liver extract injections could improve anemia and general weakness in convalescent patients, likely due to these nutrients.

While modern medicine has largely shifted to targeted supplementation (such as pure vitamin B12 or iron), there is still some scientific rationale for using liver fractions in cases where patients may be malnourished or have increased nutrient needs during recovery. However, direct clinical trials in recent decades are lacking, and the evidence base is not robust by current standards. Most support comes from older studies and biochemical reasoning. Thus, while scientific reasoning exists—especially for correcting anemia or nutrient deficiencies—the quality and quantity of modern evidence is moderate, justifying a rating of 3 out of 5.

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Integrative Therapeutics Iron Complex