Mushrooms, particularly certain medicinal varieties such as Lentinula edodes (shiitake), Ganoderma lucidum (reishi), and Coriolus versicolor (turkey tail), have been studied for their potential role in supporting recovery during convalescence. Scientific research indicates that these mushrooms contain bioactive compounds, notably beta-glucans and polysaccharides, which may modulate immune function. Several clinical and preclinical studies suggest that these compounds can enhance immune responses, reduce inflammation, and support overall vitality, which are beneficial during recovery from illness, surgery, or debilitation.

For example, shiitake mushroom supplementation has been shown in some human studies to improve immune markers, such as increased natural killer cell activity and improved cytokine profiles. Reishi mushroom has been researched for its adaptogenic properties and potential to reduce fatigue and improve well-being in people recovering from illness. However, much of the evidence is preliminary, with limited large-scale, high-quality clinical trials specifically examining convalescence as an endpoint. The use of medicinal mushrooms for post-illness recovery is also supported by traditional use in East Asian medicine, but modern research provides a moderate scientific basis for their role in supporting convalescence, primarily through immune modulation and anti-inflammatory effects.