Evidence supporting the use of: Pyrroloquinoline disodium salt
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyrroloquinoline quinone disodium salt (PQQ) is a redox cofactor and antioxidant compound that has garnered scientific interest for its potential role in supporting cellular energy metabolism and recovery processes. In the context of convalescence—the period of recovery after illness or medical treatment—PQQ has been studied primarily for its ability to support mitochondrial biogenesis and reduce oxidative stress, both of which are important for tissue repair and overall recovery.

Preclinical studies have demonstrated that PQQ can stimulate the generation of new mitochondria (mitochondrial biogenesis) and enhance mitochondrial function in animal models. Improved mitochondrial function is associated with increased cellular energy (ATP) production, which is crucial during periods of healing and convalescence. Additionally, PQQ’s antioxidant properties may help mitigate cellular damage caused by oxidative stress, further supporting recovery.

However, direct clinical evidence supporting the use of PQQ specifically for convalescence in humans remains limited. Most human studies have focused on its effects on cognitive function, fatigue, and markers of oxidative stress, rather than on recovery from illness or surgery. While these findings suggest a plausible benefit in supporting recovery, high-quality randomized controlled trials directly assessing PQQ’s impact on convalescence are lacking. Therefore, while there is a scientific rationale and some supportive evidence from animal and indirect human studies, the overall evidence remains preliminary, justifying a moderate rating.

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