Evidence supporting the use of: Vitamin B1 (fursultiamine)
For the health condition: Convalescence

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B1 (fursultiamine) is a synthetic derivative of thiamine, designed to improve bioavailability compared to standard thiamine salts. Thiamine itself is an essential nutrient that plays a key role in carbohydrate metabolism and nervous system function. Thiamine deficiency is well-documented to cause conditions such as beriberi and Wernicke-Korsakoff syndrome. During periods of convalescence—recovery from illness, injury, or surgery—nutritional requirements may be increased, and deficiencies can impede recovery. There is a scientific rationale for ensuring adequate thiamine status in such settings, particularly in malnourished individuals or those with conditions that predispose to deficiency (e.g., chronic alcohol use, malabsorption). However, specific clinical trials directly evaluating fursultiamine or thiamine supplementation as a targeted therapy to accelerate or enhance convalescence in otherwise well-nourished individuals are limited. Most evidence is extrapolated from studies in deficiency states or in populations at risk of deficiency. Some small studies and reviews mention improved appetite, energy, and well-being in patients receiving thiamine during recovery, but robust, high-quality evidence is lacking. The use of fursultiamine in convalescence is thus scientifically plausible and sometimes practiced, especially where deficiency is likely, but the overall strength of direct evidence supporting its use specifically for convalescence is considered low to moderate.

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