Evidence supporting the use of: Uncaria rhynchophylla
For the health condition: Convulsions

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Uncaria rhynchophylla, known as Gou Teng in traditional Chinese medicine, has both a historical and scientific basis for its use in managing convulsions. Traditionally, it has been used in East Asian medicine to "extinguish wind" and alleviate symptoms such as tremors, spasms, and convulsions, particularly in pediatric patients and those with neurological disorders. This use is well-documented in classical texts and continues in modern herbal practice.

From a scientific perspective, several preclinical studies have explored the anticonvulsant properties of Uncaria rhynchophylla. Experimental research using animal models of epilepsy and chemically induced seizures has shown that extracts of this herb, as well as its main alkaloid constituents such as rhynchophylline and isorhynchophylline, exhibit significant anticonvulsant effects. These effects are thought to be mediated by modulation of neurotransmitters (especially glutamate and GABA), inhibition of NMDA receptor activity, and neuroprotective actions that reduce neuronal excitability and oxidative stress.

Despite promising preclinical results, there is still a lack of robust clinical trials in humans to confirm its efficacy and safety for convulsions or epilepsy. Thus, while the scientific rationale exists and the traditional use is well-established, the evidence is currently limited to laboratory and animal studies, justifying a moderate evidence rating.

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