Evidence supporting the use of: Acetyl L-Tyrosine
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl L-Tyrosine is an acetylated form of the amino acid L-tyrosine, which serves as a precursor for the synthesis of catecholamines such as dopamine, norepinephrine, and epinephrine. These neurotransmitters are involved in the body's response to stress, with their synthesis being upregulated during periods of acute stress, which also leads to elevations in cortisol levels. Some research suggests that supplemental tyrosine (including acetyl L-tyrosine) can help maintain cognitive performance and mood under stressful conditions, possibly by supporting catecholamine synthesis when the body's demand for these neurotransmitters is high. However, direct evidence linking acetyl L-tyrosine supplementation to the regulation of cortisol itself is limited. Most studies focus on stress resilience and cognitive performance rather than direct modulation of cortisol levels. While there is a plausible biochemical rationale for its use in supporting neurotransmitter systems related to the stress response, robust clinical trials demonstrating a clear, direct impact on cortisol levels are lacking. Therefore, the scientific support for acetyl L-tyrosine’s use specifically for "supporting the cortisol body system" is modest, with evidence more robust for its role in supporting neurotransmitter function during stress rather than direct cortisol modulation.

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