Evidence supporting the use of: Apigenin
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a naturally occurring flavonoid found in various plants, including parsley, chamomile, and celery. Its use for supporting the cortisol system is primarily based on preliminary scientific evidence. Cortisol is a glucocorticoid hormone produced by the adrenal glands and is involved in the body's stress response. Studies, mostly in vitro and in animal models, have demonstrated that apigenin can influence the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production. For example, animal studies have shown that apigenin may decrease corticosterone (the rodent equivalent of cortisol) levels and modulate stress-induced behavioral and biochemical changes. Some mechanisms proposed include inhibition of corticotropin-releasing hormone (CRH) expression, reduction in oxidative stress, and modulation of GABAergic signaling, which collectively may contribute to reduced cortisol or stress responses.

However, direct human clinical evidence supporting apigenin's effects on cortisol regulation is limited. Most of the supportive data comes from preclinical research, and human trials are lacking or inconclusive. As a result, while there is some scientific rationale and early-stage evidence for apigenin supporting the cortisol system, the overall evidence level remains modest (rated 2/5), and more rigorous clinical studies are needed to confirm these effects in humans.

More about Apigenin
More about Cortisol

Products containing Apigenin

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